Capecitabine Xeloda Hand Foot Syndrome

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Capecitabine (Xeloda) Hand Foot Syndrome teaches about the dermatological adverse effects of the antineoplastic drug Xeloda.
Table of Contents:
Capecitabine (Xeloda) Indications
Capecitabine (Xeloda) Contraindications
Capecitabine (Xeloda) Hand Foot Syndrome Symptoms and Treatment
Other Dermatological Capecitabine (Xeloda) Side Effects
Other Capecitabine (Xeloda) Adverse Effects
Capecitabine (Xeloda) Drug Interactions

Book Excerpt
Capecitabine Indications
Capecitabine (Xeloda) is a prodrug of 5 deoxy 5 fluorouridine which is converted to 5 fluorouracil (5 FU) in the body. This antineoplastic drug works by retarding or stopping the growth of cancer cells and decreasing the tumor size Though the Capecitabine (Xeloda) dose depends on body size and response to treatment, the common dosage is 1250 mg/ m2 twice daily for two weeks then stopped for one week. This orally administered tablet with tumor selective conversion of capecitabine to 5 FU is used to treat:
1. Metastatic colorectal cancer (cancer of the colon and rectum that has spread to other parts of the body)
2. Metastatic breast cancer (breast cancer that has spread to other parts of the body)
3. Advanced gastric cancer (stomach cancer that has spread to other parts of the body)

Capecitabine Contraindications
Capecitabine (Xeloda) should not be taken by the following patients:
1. Patients who are breastfeeding as it can pass through the breast milk and affect the baby.
2. Patients who are deficient of the enzyme dihydropyrimidine dehydrogenase (DPD)
3. Patients who are allergic to 5FU  or capecitabine

Capecitabine (Xeloda) Hand Foot Syndrome Symptoms and Treatment
Hand foot syndrome (HFS), which is also known as palmo plantar erythrodysesthesia (PPE), is seen in almost 50% of patients treated with capecitabine.

HFS usually begins with dysesthesias such as tingling or burning sensations in the soles and palms. These are usually followed by a burning pain with symmetrical erythematous (red) swelling of the hands and feet. This can progress to blistering, ulceration, and painful desquamation (peeling) of the hands and feet.

Though the lesions of HFS are not life threatening, they can interfere with activities of normal daily living such as walking and using the hands to hold and manipulate objects. 

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